Overexpressed ribosomal proteins suppress defective chaperonins inSaccharomyces cerevisiae
نویسندگان
چکیده
منابع مشابه
Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis.
The Saccharomyces cerevisiae RPS0A/B genes encode proteins of the 40S ribosomal subunit that are required for the maturation of 18S rRNA. We show here that the RPS0 genes interact genetically with TOM1. TOM1 encodes a member of the hect-domain-containing E3 ubiquitin-protein ligase family that is required for growth at elevated temperatures. Mutant alleles of the RPS0 and TOM1 genes have synerg...
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For most proteins of the eukaryotic cytosol, the folding pathways are still largely a mystery, even though many cytosolic chaperones have been identified, including multiple members of the heat shock protein (Hsp) 70 family, Hsp90 and the chaperonin, CCT/TRiC. Particularly puzzling has been the role of CCT, a distant cousin of the prokaryotic chaperonin GroEL, found in eukaryotes and archea. Gr...
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ژورنال
عنوان ژورنال: FEMS Yeast Research
سال: 2008
ISSN: 1567-1356,1567-1364
DOI: 10.1111/j.1567-1364.2008.00425.x